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  • Title: Solitary mandibular metastasis as an initial manifestation of hepatocellular carcinoma.
    Author: Teshigawara K, Kakizaki S, Sohara N, Hashida T, Tomizawa Y, Sato K, Takagi H, Mori M, Hoshino K, Mogi K.
    Journal: Acta Med Okayama; 2006 Aug; 60(4):243-7. PubMed ID: 16943863.
    Abstract:
    Oral metastases from hepatocellular carcinoma are very rare. We encountered a case of hepatocellular carcinoma with a solitary metastasis to the mandible as an initial manifestation. The patient was a 76-year-old man who was admitted for left mandibular swelling. A biopsy specimen of mandible was suspected to be a metastatic tumor. The histological findings, abdominal computed tomography, bone scintigraphy, and F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) revealed it to be a solitary metastasis from hepatocellular carcinoma. As a result, he was diagnosed to have liver cirrhosis due to a hepatitis C virus infection and hepatocellular carcinoma with a solitary metastasis to the mandible. The primary lesion was treated with transcatheter arterial embolization (TAE), and the metastasis to the mandible was surgically resected. The patient survived for 9 months after treatment without recurrence.
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