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  • Title: Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma.
    Author: Chamberlain MC, Glantz MJ, Chalmers L, Van Horn A, Sloan AE.
    Journal: J Neurooncol; 2007 Mar; 82(1):81-3. PubMed ID: 16944309.
    Abstract:
    Concurrent temozolomide (TMZ) and radiotherapy is the new standard of care for patients with newly diagnosed glioblastoma. In 51 consecutive patients treated according to this regimen, 7 patients (14%) manifested surgically confirmed early necrosis without evidence of recurrent tumor. This observation suggests that daily TMZ may represent a potent radiosensitizing regimen.
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