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  • Title: Association of matrix metalloproteinase-9 promoter gene polymorphism with chronic periodontitis.
    Author: Keles GC, Gunes S, Sumer AP, Sumer M, Kara N, Bagci H, Koprulu H.
    Journal: J Periodontol; 2006 Sep; 77(9):1510-4. PubMed ID: 16945027.
    Abstract:
    BACKGROUND: Matrix metalloproteinases (MMPs) are related to tissue destruction and remodeling events in periodontal diseases. A single nucleotide polymorphism in the promoter region of human MMP-9 gene is associated with the risk of some inflammatory diseases. Therefore, the aim of this study was to investigate the association between MMP-9 promoter polymorphism and severe generalized chronic periodontitis in a Turkish population. METHODS: Samples of venous blood and DNA were obtained from 70 severe generalized chronic periodontitis patients and 70 healthy subjects. The alleles of the C/T polymorphism at position -1562 in the promoter region of the MMP-9 gene were distinguished by cutting with the SphI restriction enzyme. Genotype and allele frequencies were calculated, and data were analyzed by the chi2 test. RESULTS: There was a significant difference in MMP-9 genotypes between chronic periodontitis patients and healthy controls. The odds ratios for the CT genotype and the combination of CT and TT genotypes were 0.4 (95% confidence interval, 0.17 to 0.93; P=0.02) and 0.37 (95% confidence interval, 016 to 0.85; P=0.01) relative to the subjects with the CC genotype, respectively. CONCLUSION: MMP-9 promoter gene polymorphism seems to be associated with severe generalized chronic periodontitis.
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