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  • Title: QSAR study of antiplatelet agents.
    Author: Katritzky AR, Pacureanu LM, Slavov S, Dobchev DA, Karelson M.
    Journal: Bioorg Med Chem; 2006 Nov 15; 14(22):7490-500. PubMed ID: 16945540.
    Abstract:
    A QSAR methodology that involves multilinear (Hansch-type) and nonlinear (ANN backpropagation) approaches was developed to correlate the antiplatelet activity of 60 benzoxazinone derivatives against factor Xa. The statistical characteristics provided by multilinear model (R2 = 0.821) indicated satisfactory stability and predictive ability, while the ANN predictive ability is somewhat superior (R2 = 0.909). The multilinear model provided insight into the main factors that modulate the inhibitory activity of the investigated compounds.
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