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  • Title: Membrane depolarization inhibits thrombin-induced calcium influx and aggregation in human platelets.
    Author: Kovács T, Tordai A, Szász I, Sarkadi B, Gárdos G.
    Journal: FEBS Lett; 1990 Jun 18; 266(1-2):171-4. PubMed ID: 1694785.
    Abstract:
    The relationship between thrombin-evoked changes in intracellular calcium concentration [( Ca2+]i) and aggregation was examined in Indo-1-loaded human platelets. The stimulus-induced intracellular calcium release and external calcium influx, as well as platelet aggregation, were studied in the same cell preparation. A close correlation between the sustained high [Ca2+]i level, depending on calcium entry, and the aggregation response was found. Gramicidin, at a concentration high enough to induce membrane depolarization, strongly inhibited the calcium influx and aggregation, but did not influence the thrombin-induced intracellular calcium release. We conclude that calcium influx through depolarization-inhibited calcium channels is a prerequisite of thrombin-induced platelet aggregation.
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