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  • Title: Effects of alpha-substitutions on structure and biological activity of anticancer chalcones.
    Author: Lawrence NJ, Patterson RP, Ooi LL, Cook D, Ducki S.
    Journal: Bioorg Med Chem Lett; 2006 Nov 15; 16(22):5844-8. PubMed ID: 16949281.
    Abstract:
    Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different alpha-substitutions, in particular alpha-fluorination, on the structure and biological activity of a series of chalcones.
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