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  • Title: Preeclampsia and subsequent risk of cancer in Utah.
    Author: Aagaard-Tillery KM, Stoddard GJ, Holmgren C, Lacoursiere DY, Fraser A, Mineau GP, Varner MW.
    Journal: Am J Obstet Gynecol; 2006 Sep; 195(3):691-9. PubMed ID: 16949398.
    Abstract:
    OBJECTIVE: The purpose of this study was to determine if preeclampsia is associated with a reduced risk of cancer later in life. STUDY DESIGN: We performed a cohort study where women with preeclampsia over the interval 1947 to 1999 were identified from the Utah Population Database. Preeclamptics (n = 17,432) were matched 1:3 with nonpreeclamptics (n = 52,296) on maternal age and birth year. Pregnancy, demographic, and cancer information was extracted from subjects and their offspring in linked datasets. Relative risk and hazard ratios were calculated. RESULTS: In a matched analysis using univariable random-effects Poisson regression, preeclampsia was protective against the development of cancer later in life (RR 0.91, 95% CI 0.84-0.99 with P = .027). In a multivariable clustered Cox regression model with the end point of cancer later in life, preeclampsia was associated with a lower risk of cancer (HR 0.92, 95% CI 0.85-0.99 with P = .039). These findings were supported by stratified and competing risk analyses. CONCLUSION: Women whose pregnancies were affected by preeclampsia have a decreased risk of developing cancer.
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