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  • Title: Lack of neuropeptide Y attenuates the somatic signs of opiate withdrawal.
    Author: Olson VG, Griner NB, Heusner CL, Palmiter RD.
    Journal: Synapse; 2006 Dec 01; 60(7):553-6. PubMed ID: 16952158.
    Abstract:
    Recent evidence suggests that neuropeptide Y (NPY) may be involved in the neurobiological responses to drugs of abuse. This study was designed to assess the possible contribution of NPY to opiate withdrawal behaviors. Here we report that mice lacking the NPY gene show normal conditioned place aversion to opiate withdrawal, but show attenuated opiate withdrawal somatic signs.
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