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  • Title: Conjunctival Splendore-Hoeppli phenomenon in a 3-year-old child.
    Author: Orhan D, Kiratli H, Kocabeyoğlu S.
    Journal: Pediatr Dev Pathol; 2006; 9(5):388-90. PubMed ID: 16953679.
    Abstract:
    A case of benign granulomas of the conjunctiva in a 3-year-old girl is reported. Histologic features of the excised conjunctival lesions were consistent with Splendore-Hoeppli phenomenon. This phenomenon is thought to be a granulomatous reaction to an antigen-antibody precipitate related to parasites or fungi. No causative agent is identified in our patient. Immunohistochemical analysis showed no immunoreactivity for immunoglobulin G (IgG), IgM, IgA, or the C3 component of the complement. We propose that the presence of small amelanotic nodular conjunctival tumors should arouse suspicion related to the Splendore-Hoeppli phenomenon even in early childhood.
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