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  • Title: Ischaemia and mediator release: interrelationship in antigen-challenged sensitized guinea-pig kidney.
    Author: Abdullah NA, Assem ES.
    Journal: Agents Actions; 1990 Apr; 30(1-2):106-9. PubMed ID: 1695424.
    Abstract:
    Renal vasoconstriction and ischaemia that follow in vitro antigen challenge of isolated perfused kidney of sensitized guinea-pig appears to be a self-perpetuating process, starting with a primary peak of release of vasoconstrictor mediators and followed by secondary peaks (particularly of arachidonic acid metabolites) which are probably initiated by ischaemia/reperfusion damage.
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