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  • Title: Invader plus method detects herpes simplex virus in cerebrospinal fluid and simultaneously differentiates types 1 and 2.
    Author: Allawi HT, Li H, Sander T, Aslanukov A, Lyamichev VI, Blackman A, Elagin S, Tang YW.
    Journal: J Clin Microbiol; 2006 Sep; 44(9):3443-7. PubMed ID: 16954297.
    Abstract:
    We report here on the development and validation of a prototype Invader Plus method for the qualitative detection of herpes simplex virus types 1 and 2 in cerebrospinal fluid (CSF). The method combines PCR and Invader techniques in a single, closed-tube, continuous-reaction format that gives an analytical sensitivity of approximately 10 copies per reaction. The clinical sensitivity and specificity were 100.0% and 98.6%, respectively, when the results of the method were validated against the results obtained with a PCR colorimetric microtiter plate system by use of clinical CSF specimens.
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