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  • Title: Agesamides A and B, bromopyrrole alkaloids from sponge Agelas species: application of DOSY for chemical screening of new metabolites.
    Author: Tsuda M, Yasuda T, Fukushi E, Kawabata J, Sekiguchi M, Fromont J, Kobayashi J.
    Journal: Org Lett; 2006 Sep 14; 8(19):4235-8. PubMed ID: 16956195.
    Abstract:
    Diffusion-ordered NMR spectroscopy (DOSY) is a versatile and powerful NMR technique and a noninvasive analytical method for mixture analysis that does not require prior physical separation of the analytes. In our search for new metabolites from natural resources, DOSY was applied for constituent analysis of crude bromopyrrole fractions separated from an Okinawan marine sponge Agelas sp. so that two new bromopyrrole alkaloids, agesamides A (1) and B (2), have been isolated. The structures and relative stereochemistry of 1 and 2 were elucidated from spectroscopic data.
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