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  • Title: Determination of a unique and immunodominant epitope of human T cell lymphotropic virus type I.
    Author: Lipka JJ, Bui K, Reyes GR, Moeckli R, Wiktor SZ, Blattner WA, Murphy EL, Shaw GM, Hanson CV, Sninsky JJ.
    Journal: J Infect Dis; 1990 Aug; 162(2):353-7. PubMed ID: 1695653.
    Abstract:
    The identification and isolation of unique and immunogenic recombinant epitopes for human T cell lymphotrophic virus (HTLV) type I might allow the development of an antibody-based assay to differentiate between HTLV-I and HTLV-II infections. To test the feasibility of this approach, an HTLV-I envelope epitope was isolated by immunoscreening of a lambda gt11 recombinant HTLV-I DNA library with a human monoclonal antibody to HTLV-I. This recombinant epitope. MTA-4, when tested with sera from HTLV-I- or HTLV-II-infected individuals, was reactive with all HTLV-I and nonreactive with all HTLV-II antisera. These results indicate that MTA-4 is a unique and immunodominant epitope on HTLV-I and confirm the usefulness of human-derived monoclonal antibodies in an experimental approach to dissect the human humoral response to a viral pathogen.
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