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  • Title: Cloned Theileria parva produces lesser infections in ticks compared to uncloned T. parva despite similar infections in cattle.
    Author: Walker AR, Katzer F, Ngugi D, McKeever D.
    Journal: Onderstepoort J Vet Res; 2006 Jun; 73(2):157-62. PubMed ID: 16958269.
    Abstract:
    Experimental transmissions of cloned Theileria parva in cattle with Rhipicephalus appendiculatus ticks were compared to transmissions with uncloned T. parva during studies on the potential for genetic recombination during syngamy of Theileria to produce antigenic diversity for evasion of bovine immunity. Prevalence and abundance of T. parva infection in adult ticks, which resulted from the feeding of nymphs on the calves, were significantly higher in the uncloned compared to the cloned T. parva. Development of sporoblasts of T. parva in the ticks to produce infective sporozoites was similar. There was no statistically significant difference in the clinical course of infection in cattle between cloned and uncloned T. parva. It was concluded that cloned T. parva has characteristics that reduce its viability during the tick stages of its life cycle.
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