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  • Title: Stereoselective synthesis of highly functionalized nitrocyclopropanes via organocatalyic conjugate addition to nitroalkenes.
    Author: McCooey SH, McCabe T, Connon SJ.
    Journal: J Org Chem; 2006 Sep 15; 71(19):7494-7. PubMed ID: 16958552.
    Abstract:
    A convenient and novel one-pot organocatalytic methodology for the stereoselective synthesis of highly functionalized nitrocyclopropanes is reported. The addition of dimethyl chloromalonate to a variety of nitroolefins catalyzed by tertiary amines leads to a Michael adduct which cyclizes to form the cyclopropane in the presence of DBU under carefully controlled reaction conditions with outstanding diastereoselectivity.
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