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  • Title: Distribution and translocation of photoreceptor Gbetagamma-phosducin system in medaka retina.
    Author: Yamamoto S, Hisatomi O, Hasegawa A, Kobayashi Y, Tokunaga F.
    Journal: Photochem Photobiol; 2007; 83(1):35-9. PubMed ID: 16958559.
    Abstract:
    Unlike other vertebrates, teleosts have rod- and cone-specific phosducins (PD-R and PD-C) in the retina. To evaluate the teleost Gbetagamma-PD systems, we isolated cDNAs encoding medaka Gbeta1 and GbetaC, which selectively expressed rods and cones. Immunohistochemical studies showed that the strong reactivity of GbetaC but not PD-C was detected in cone outer segments. In rod outer segments (ROS), PD-R reactivity was stronger in light-adapted retina than in dark-adapted retina. Western blot analyses of fractions torn from the cryosections showed that the PD-R concentration was low in dark-adapted ROS. It is suggested that PD-R is translocated to ROS and effectively downregulates the phototransduction cascade in light-adapted rods.
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