These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of N-methyl-D-aspartate on extracellular citrulline level in the rat nucleus accumbens.
    Author: Saulskaya NB, Fofonova NV.
    Journal: Neurosci Lett; 2006 Oct 16; 407(1):91-5. PubMed ID: 16959422.
    Abstract:
    In vivo microdialysis combined with high-performance liquid chromatography and electrochemical detection was used to study effects of intraaccumbal infusion of N-methyl-D-aspartate (NMDA) on the content of extracellular citrulline (a nitric oxide co-product) in the medial nucleus accumbens of Sprague-Dawley rats. The intraaccumbal NMDA infusion (10-1000 microM) dose-dependently increased the local dialysate citrulline levels (193+/-7% and 258+/-7% versus basal for the 100 and 1000 microM, respectively). The NMDA-induced increase of extracellular citrulline was completely prevented by intraaccumbal infusions through the dialysis probe both of 50 microM dizocilpine maleate (an NMDA antagonist) and of 0.5 mM N-nitro-L-arginine (a nitric oxide synthase inhibitor). Local infusion of N-nitro-L-arginine (0.5 mM) slightly decreased basal citrulline levels in the nucleus accumbens throughout the entire period of the infusion, whereas dizocilpine maleate (50 microM) had no long-lasting effect. These results suggest that NMDA receptor stimulation of the medial nucleus accumbens might cause a local nitric oxide synthase activation resulting in nitric oxide production in this brain area.
    [Abstract] [Full Text] [Related] [New Search]