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  • Title: Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy.
    Author: Lee PH, Yeo SH, Kim HJ, Youm HY.
    Journal: Mov Disord; 2006 Nov; 21(11):1975-7. PubMed ID: 16960860.
    Abstract:
    We investigated an association between olfaction and cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross-Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD.
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