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  • Title: CSF metabolites in borderline personality disorder compared with normal controls.
    Author: Gardner DL, Lucas PB, Cowdry RW.
    Journal: Biol Psychiatry; 1990 Aug 01; 28(3):247-54. PubMed ID: 1696137.
    Abstract:
    Cerebrospinal metabolites were measured in 17 patients with borderline personality disorder and 17 normal controls. There were no significant differences between the two groups in levels of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), or 3-methoxy-4-hydroxyphenylglycol (MHPG). Within the borderline group, lower levels of CSF 5-HIAA were significantly associated with a history of genuine suicide attempts, but were not associated with violence, self-mutilation, or with the presence of major depression. Thus, CSF 5-HIAA levels are not distinctively low in a diagnostic group characterized by impulsivity and suicidal behavior, but within that group may be associated with genuine suicide attempts.
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