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  • Title: Structure-activity relationship for inhibition of 5alpha-reductase by triterpenoids isolated from Ganoderma lucidum.
    Author: Liu J, Kurashiki K, Shimizu K, Kondo R.
    Journal: Bioorg Med Chem; 2006 Dec 15; 14(24):8654-60. PubMed ID: 16962782.
    Abstract:
    In humans, 5alpha-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5alpha-reductase activity. The presence of the C-3 carbonyl group and of the C-26-alpha,beta-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum.
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