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  • Title: Capsaicin-sensitive and hexamethonium-insensitive circular muscle responses to mesenteric nerve stimulation in the isolated guinea pig ileum.
    Author: Takaki M, Jin JG, Nakayama S.
    Journal: Acta Med Okayama; 1990 Jun; 44(3):135-9. PubMed ID: 1696423.
    Abstract:
    Capsaicin-sensitive and hexamethonium-insensitive contractile and relaxatory motor responses of circular muscle induced by mesenteric nerve stimulation were studied. Desensitization to substance P or to neurokinin A, or the substance P antagonist, spantide largely reduced the initial contractile response. Desensitization to calcitonin gene-related peptide moderately reduced the late prolonged relaxation response. These results indicate that both responses of the circular muscle to mesenteric nerve stimulation may be attributed to a release of neuropeptides evoked by the 'efferent' stimulation of capsaicin-sensitive sensory nerves.
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