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  • Title: Calcium-dependent effect of gentamicin on glucose formation in isolated rabbit kidney-cortex tubules.
    Author: Michalik M, Biedermann I, Bryła J.
    Journal: Ren Physiol Biochem; 1990; 13(5):269-74. PubMed ID: 1697088.
    Abstract:
    In contrast to the inhibition by gentamicin of glucose production from propionate, pyruvate and lactate in renal tubules incubated at 2.5 mM Ca2+, this antibiotic does not affect gluconeogenesis from propionate and lactate, and significantly stimulates this process from other substrates at 0.5 mM Ca2+. This may be due to the gentamicin-induced increase of the cytosolic manganese content (from 1.7 to 2.7 nmol/mg protein), resulting in a stimulation of cytosolic phosphoenolpyruvate carboxykinase activity. At 2.5 mM Ca2+ the cytosolic Mn content (2.7 nmol/mg protein) seems to be high enough to accomplish activation of the enzyme.
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