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  • Title: Synthesis of three classes of rhodacyanine dyes and evaluation of their in vitro and in vivo antimalarial activity.
    Author: Pudhom K, Kasai K, Terauchi H, Inoue H, Kaiser M, Brun R, Ihara M, Takasu K.
    Journal: Bioorg Med Chem; 2006 Dec 15; 14(24):8550-63. PubMed ID: 16971131.
    Abstract:
    Selected members of three classes of rhodacyanine dyes, [0,0]-, [1,0]-, and [0,0,0]-rhodacyanines, were synthesized and their in vitro antimalarial activities against Plasmodium falciparum K1 (chloroquine-resistant strain) as well as their in vivo activities against P. berghei in mice were determined. The novel [0,0,0]-rhodacynines, 3e and 3h, possessing a benzothiazole moiety, were shown to have highly promising antimalarial activities in vivo. Moreover, the [0,0,0]-rhodacyanines were found to be orally bioavailable.
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