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  • Title: Simultaneous detection of creatine and creatinine using a sequential injection analysis/biosensor system.
    Author: Stefan-van Staden RI, Bokretsion RG, van Staden JF, Aboul-Enein HY.
    Journal: Prep Biochem Biotechnol; 2006; 36(4):287-96. PubMed ID: 16971300.
    Abstract:
    Carbon paste based biosensors for the determination of creatine and creatinine have been integrated into a sequential injection system. Applying the multi-enzyme sequence of creatininase (CA), and/or creatinase (CI) and sarcosine oxidase (SO), hydrogen peroxide has been detected amperometrically. The linear concentration ranges are of pmol/L to nmol/L magnitude, with very low limits of detection. The proposed SIA system can be utilized reliably for the on-line simultaneous detection of creatine and creatinine in pharmaceutical products, as well as in serum samples, with a rate of 34 samples per hour and RSD values better than 0.16% (n=10).
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