These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antiphasic Purkinje cell responses in mouse uvula-nodulus are sensitive to static roll-tilt and topographically organized.
    Author: Yakhnitsa V, Barmack NH.
    Journal: Neuroscience; 2006 Dec 01; 143(2):615-26. PubMed ID: 16973298.
    Abstract:
    Two vestibular pathways converge at the uvula-nodulus to modulate the discharge of Purkinje cell complex and simple spikes (CSs and SSs). In the mouse, vestibular primary afferent mossy fibers originate from each of the end organs of the ipsilateral labyrinth and terminate in the granule cell layers of folia 9c-10. Vestibular climbing fiber projections originate from the contralateral beta-nucleus and dorsomedial cell column (dmcc) and terminate directly on Purkinje cells. CSs and SSs could be regulated independently or they could be co-dependent. Here we examine how the discharges of CSs and SSs are modulated by sinusoidal and static roll-tilt in the uvula-nodulus of mice anesthetized with either chloralose-urethane or ketamine-xylazine. All vestibularly-driven CSs and SSs were sensitive to static roll-tilt. None were sensitive to horizontal vestibular stimulation. CSs were modulated in phase with ipsilateral roll-tilt. SSs were modulated out of phase. Spontaneous discharges of CSs were followed by a pause in SSs. Phase leads of CSs and SSs with respect to sinusoidal roll-tilt were advanced by ketamine-xylazine anesthesia relative to chloralose-urethane anesthesia by approximately 45 degrees. The antiphasic modulation of CSs and SSs was independent of anesthetic. Chloralose-urethane, but not ketamine-xylazine, induced spontaneous oscillations of CSs and SSs in 16% of Purkinje cells. Optimal planes of CSs in folia 9c-10 Purkinje cells were organized topographically into sagittal zones whose widths were approximately 400 microm. Purkinje cells with optimal planes in the posterior quadrant of the ipsilateral hemi-field were located in a medial zone. Purkinje cells with optimal planes in the anterior quadrant of the ipsilateral hemi-field were located in a lateral zone. The CS-associated pause in SSs establishes a vector-specific SS output. The amplitude of SS modulation may depend on parallel fiber-mediated signals to Purkinje cells as well as on the state of cerebellar interneurons.
    [Abstract] [Full Text] [Related] [New Search]