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  • Title: Increased levels of pigment epithelium-derived factor in aqueous humor of patients with uveitis.
    Author: Yoshida Y, Yamagishi S, Matsui T, Nakamura K, Imaizumi T, Yoshimura K, Yamakawa R.
    Journal: Br J Ophthalmol; 2007 Feb; 91(2):149-50. PubMed ID: 16973658.
    Abstract:
    AIM: To evaluate whether aqueous humor levels of pigment epithelium-derived factor (PEDF) are increased in patients with uveitis METHODS: Aqueous humor levels of PEDF and tumour necrosis factor alpha (TNFalpha) were determined by ELISA in 34 uveitis samples and 9 cataract control samples. RESULTS: Aqueous humor PEDF and TNFalpha levels were significantly higher in patients with uveitis than in controls (mean (SD) 6.4 (0.8) v 1.3 (0.2) microg/ml and 14.7 (3.8) v 4.2 (0.4) pg/ml, respectively; p<0.01). A positive correlation between PEDF and TNFalpha was found in patients with uveitis (r = 0.40, p<0.01). Furthermore, PEDF levels in aqueous humor were increased in proportion to the disease activity of uveitis. CONCLUSION: The results show that aqueous humor levels of PEDF are increased in patients with uveitis. Our observations suggest that aqueous humor levels of PEDF may be increased as a countersystem against inflammation in uveitis.
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