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  • Title: Effect of topical nipradilol on retinal microvascular leukocyte adhesion in diabetic rats.
    Author: Ono R, Kakehashi A, Ito Y, Sugi N, Makino S, Kobayashi E, Hakamada Y, Takagi Y, Kitazume Y, Kawakami M.
    Journal: Ophthalmic Res; 2006; 38(5):270-3. PubMed ID: 16974127.
    Abstract:
    BACKGROUND: Retinal leukostasis plays an important role in the pathogenesis of diabetic retinopathy. OBJECTIVES: We studied the effects of nipradilol, a topical antiglaucoma alphabeta-blocker and nitric oxide donor, on the retinal vascular leukocyte adhesion of rats with diabetes. METHODS: Diabetes was induced in seven Brown-Norway rats by one intravenous injection (65 mg/kg) of streptozotocin and confirmed by blood glucose levels >350 mg/dl 48 h after the injection. Nipradilol solution was instilled in the right eye and nipradilol-free base solution in the left eye for 3 weeks, after which the retinal microcirculation was evaluated by acridine orange leukocyte digital fluorography using laser scanning ophthalmoscopy. Leukocytes trapped in the retina were counted around the optic disc in a 5-disc-diameter area and compared between the right and the left eye. RESULTS: The mean retinal leukostasis count in the nipradilol-treated eyes (19 +/- 15 cells) was significantly lower than in the untreated eyes (49 +/- 19 cells; p < 0.0008). The diameter of the retinal artery in the eyes treated with nipradilol significantly increased (111 +/- 13.5%) compared with untreated eyes (p < 0.03). CONCLUSIONS: Topical nipradilol significantly reduced retinal leukostasis in the retinal microcirculation in diabetic rats and may be a prophylactic agent for early diabetic retinopathy through its nitric oxide donor effects on the microcirculation.
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