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  • Title: Studies on the non-activated and activated forms of the estrogen receptor.
    Author: Pasqualini JR, Giambiagi N.
    Journal: Rev Esp Fisiol; 1990 Mar; 46(1):1-7. PubMed ID: 1697692.
    Abstract:
    The activation of the steroid receptor is a necessary process for the biological role of the receptor. Many factors are involved in this mechanism; in addition to time, temperature, and salt concentration, RNA and RNAase can also affect the transformation of the non-activated to the activated form of the receptor. Using as a model the estrogen receptor of fetal uterus of guinea-pig, the studies of the interaction with three different monoclonal antibodies (D547, H222 and H226) reveal structural transformation during the process of the receptor activation. These conformational transformations suggest that a change in the exposure of the functional domains of the estrogen receptor occurs during activation.
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