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  • Title: A high-resolution comparative radiation hybrid map of equine chromosome 4q12-q22.
    Author: Dierks C, Mömke S, Drögemüller C, Leeb T, Chowdhary BP, Distl O.
    Journal: Anim Genet; 2006 Oct; 37(5):513-7. PubMed ID: 16978184.
    Abstract:
    In this study, we present a comprehensive 5000-rad radiation hybrid map of a 40-cM region on equine chromosome 4 (ECA4) that contains quantitative trait loci for equine osteochondrosis. We mapped 29 gene-associated sequence tagged site markers using primers designed from equine expressed sequence tags or BAC clones in the ECA4q12-q22 region. Three blocks of conserved synteny, showing two chromosomal breakpoints, were identified in the segment of ECA4q12-q22. Markers from other segments of HSA7q mapped to ECA13p and ECA4p, and a region of HSA7p was homologous to ECA13p. Therefore, we have improved the resolution of the human-equine comparative map, which allows the identification of candidate genes underlying traits of interest.
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