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Title: Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro. Author: Chia YC, Chang FR, Wu CC, Teng CM, Chen KS, Wu YC. Journal: Planta Med; 2006 Oct; 72(13):1238-41. PubMed ID: 16981134. Abstract: Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)- N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships.[Abstract] [Full Text] [Related] [New Search]