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  • Title: Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease.
    Author: Metyas SK, Hoffman HM.
    Journal: J Rheumatol; 2006 Oct; 33(10):2085-7. PubMed ID: 16981288.
    Abstract:
    Familial cold autoinflammatory syndrome (FCAS) is a rare, hereditary disorder characterized by cold-induced inflammation. We describe the successful longterm treatment of a patient with FCAS with anakinra, an interleukin 1 receptor antagonist (IL-1Ra). The remarkable response of FCAS and associated Raynaud's disease in this patient suggests that IL-1 is an important mediator of these inflammatory diseases. Our report supports increasing evidence that anakinra plays an important role in the treatment of select chronic inflammatory diseases.
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