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  • Title: The N-terminal 1-16, but not C-terminal 17-29, galanin fragment affects the flexor reflex in rats.
    Author: Xu XJ, Wiesenfeld-Hallin Z, Fisone G, Bartfai T, Hökfelt T.
    Journal: Eur J Pharmacol; 1990 Jun 21; 182(1):137-41. PubMed ID: 1698160.
    Abstract:
    The biological activity of two galanin (GAL) fragments, GAL-(1-16) and GAL-(17-29), was tested in vivo by using a spinal nociceptive flexor reflex model in the rat. Intrathecal (i.t.) GAL-(1-16) had a similar biphasic effect on the flexor reflex, with facilitation at lower doses and facilitation followed by depression at higher doses, as the full length peptide GAL-(1-29). GAL-(1-16) also effectively depressed the facilitation of the flexor reflex caused by i.t. substance P (SP) or C-fiber conditioning stimulation (CS) and potentiated the depressive effect of i.t. morphine on the reflex, both actions that have been reported earlier with GAL-(1-29). In contrast, i.t. GAL-(17-29), even at high doses, did not induce changes in the amplitude of the flexor reflex, nor did it interact with the effects of i.t. SP, morphine or C-fiber CS. It is concluded that the N-terminal portion of GAL-(1-29) is critical for the biological activity of the intact peptide in the dorsal horn of the rat spinal cord. The similarity between the effects of GAL-(1-16) and GAL-(1-29) indicates that they probably act on the same GAL receptor.
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