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  • Title: [Alu-like sequences in the regions of replication initiation in plasmids p15A and R6K].
    Author: Korotkov EV.
    Journal: Izv Akad Nauk SSSR Biol; 1990; (3):359-65. PubMed ID: 1698202.
    Abstract:
    A method of computer analysis of DNA sequences has been proposed. It is based on information similarity of compared sequences and it significantly increases the usefulness of the computer analysis. This approach has been applied to the search of interconnected areas of Alu-repeats and replication origins of p15A and R6K plasmids. An Alu-like region located in the first stem of the secondary structure of RNA-1 and E. coli RNA-polymerase binding site has been found in the p15A. On R6K replication origin, Alu-like repeats have been found in the area of tandem 22 bp repeats. This comparison also allowed to reveal hidden periodicity of the sequence of human Alu-repeat. A hypothesis that explained the data obtained has been proposed. The proposed approach may be used as a method for revealing DNA sequences that have similar genetic functions.
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