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  • Title: Circulating adiponectin levels in Kawasaki disease.
    Author: Takeshita S, Takabayashi H, Yoshida N.
    Journal: Acta Paediatr; 2006 Oct; 95(10):1312-4. PubMed ID: 16982510.
    Abstract:
    AIM: To investigate the kinetics of adipocytokine in Kawasaki disease (KD). METHODS: The plasma levels of adiponectin, IL-6 and TNF-alpha were measured in 20 patients with KD, 15 patients with acute febrile diseases (disease control, DC) and 15 healthy children (HC). RESULTS: Plasma adiponectin levels in patients with acute KD were significantly lower (p < 0.01) than those with convalescent KD, DC and HC. The decreased levels of adiponectin negatively correlated with the increased levels of CRP and IL-6 in acute KD. CONCLUSION: Hypoadiponectinaemia was shown during the acute phase of KD vasculitis. The downregulation of adiponectin secreted from adipose tissue may be closely linked to upregulation of systemic pro-inflammatory markers in acute KD.
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