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  • Title: Thymidine kinase mutations conferring acyclovir resistance in herpes simplex type 1 recombinant viruses.
    Author: Sergerie Y, Boivin G.
    Journal: Antimicrob Agents Chemother; 2006 Nov; 50(11):3889-92. PubMed ID: 16982796.
    Abstract:
    Contributions of thymidine kinase (TK) mutations to acyclovir (ACV) resistance were evaluated in herpes simplex virus type 1 recombinant viruses generated using a set of overlapping cosmids and plasmids. Alterations in both conserved and nonconserved regions of the TK gene were shown to confer high levels of resistance to ACV.
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