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  • Title: Correlates of the peak height velocity in girls with idiopathic scoliosis.
    Author: Sanders JO, Browne RH, Cooney TE, Finegold DN, McConnell SJ, Margraf SA.
    Journal: Spine (Phila Pa 1976); 2006 Sep 15; 31(20):2289-95. PubMed ID: 16985455.
    Abstract:
    STUDY DESIGN: Prospective longitudinal. OBJECTIVE: Determine correlates of the peak height velocity (PHV) in girls with idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Only identifiable retrospectively, the PHV is the most useful known maturity marker in idiopathic scoliosis. Clinically useful correlates are needed to make PHV timing helpful. METHODS: A total of 24 immature girls with idiopathic scoliosis were followed with serial heights, sexual staging, skeletal ages, spinal radiographs, insulin-like growth factor (IGF)-1, IGF binding protein-3, dehydroepiandrosterone sulfate, estradiol, bone-specific alkaline phosphatase, and osteocalcin levels. These markers were correlated to PHV timing. RESULTS: There were 14 girls who had identifiable growth peaks that averaged 10.5 +/- 1.8 cm/y at age 11.7 +/- 1 years. At the PHV, all girls were Risser 0 with open triradiate cartilages. On a skeletal age radiograph, digital uncapped phalangeal epiphyses were indicative of pre-PHV and fused epiphyses of post-PHV. Capped but unfused epiphyses were indeterminate. Tanner stage 1 for breast strongly indicates pre-PHV. Stage 3 for breast and pubic hair occurred at or after the PHV, and stage 4 always occurred after PHV. Higher IGF-1 and estradiol levels after PHV are potentially discriminatory. CONCLUSIONS: The PHV occurs during Risser 0 with open triradiate cartilages. If triradiate cartilages are open, then Tanner stages, IGF-1, estradiol levels, and the appearance of the epiphyses on a skeletal age radiograph are useful in determining status before or after PHV.
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