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  • Title: Metabolism of D- and L-norgestrel in humans.
    Author: Warren RJ, Fotherby K.
    Journal: Arzneimittelforschung; 1975 Jun; 25(6):964-5. PubMed ID: 169856.
    Abstract:
    Levels of DL-norgestrel, D-norgestrel, L-norgestrel and norethisterone were measured in blood by radioimmunoassay after oral administration of the progestin to 3 healthy male subjects and the half-lives calculated. Half-lives for D-norgestrel were much lower than those of L-norgestrel and similar to those of norethisterone. Measurement of norgestrel in blood can therefore be misleading unless the biologically active D-isomer is estimated. Since there was no difference in half-lives between norgestrel and norethisterone the greater potency of the former is probably due to it more strongly binding to target organ receptors.
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