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  • Title: Increase in galanin and neuropeptide Y mRNA in locus coeruleus following acute reserpine treatment.
    Author: Gundlach AL, Rutherfurd SD, Louis WJ.
    Journal: Eur J Pharmacol; 1990 Aug 02; 184(1):163-7. PubMed ID: 1698642.
    Abstract:
    Galanin and neuropeptide Y are known to coexist with noradrenaline in neurones of the locus coeruleus. Furthermore, reserpine depletes noradrenaline from, and increases the synthesis and activity of the catecholamine-synthesizing enzyme tyrosine hydroxylase in, this nucleus. We have found by in situ hybridization of specific 35S-labelled oligonucleotide probes that a single dose of reserpine (10 mg/kg) induced a significant (70-145%) and long-lasting (up to at least 3 days) increase in the amount of galanin and neuropeptide Y mRNA in the locus coeruleus (along with the characteristic increase in tyrosine hydroxylase mRNA). These results suggest a similar reserpine-sensitive mechanism of galanin, neuropeptide Y and tyrosine hydroxylase gene regulation.
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