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  • Title: Effects of urethane and ketamine on substance P- and excitatory amino acid-induced behavior in mice.
    Author: Daló NL, Larson AA.
    Journal: Eur J Pharmacol; 1990 Aug 02; 184(1):173-7. PubMed ID: 1698643.
    Abstract:
    Urethane and ketamine were tested for their ability to alter the caudally directed binding and scratching response elicited by the intrathecal (i.t.) injection of excitatory amino acids (EAAs) or substance P (SP). EAAs, such as N-methyl-D-aspartate (NMDA), kainate acid and quisqualic acid, but not SP, were inhibited by subanesthetic doses of urethane. In contrast, SP was more sensitive than NMDA to the inhibitory effect of (+)-ketamine. (-)-Ketamine produced much less inhibition of the SP-induced behaviors than the (+)isomer. These results have important implications regarding the use of urethane and ketamine as anesthetics for studies in which these excitatory compounds are potential mediators.
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