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  • Title: Cytotoxic monotetrahydrofuran acetogenins from Disepalum plagioneurum.
    Author: Eparvier V, Nguyen VH, Thoison O, Martin MT, Sévenet T, Guéritte F.
    Journal: J Nat Prod; 2006 Sep; 69(9):1289-94. PubMed ID: 16989521.
    Abstract:
    The known plagionicin A (1) and eight new monotetrahydrofuran acetogenins, plagionicins B-D (2-4) and plagioneurins A-E (5-9), were isolated from the leaves of Disepalum plagioneurum by bioassay-guided purification. The structures of the new compounds were elucidated by spectroscopic methods. The new monotetrahydrofuran (mono-THF) acetogenins exhibited significant in vitro cytotoxicity against the KB cancer cell line, with IC(50) values in the nanomolar range.
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