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  • Title: Decreased suppression of interleukin-6 after treatment with medroxyprogesterone acetate and danazol in endometrial stromal cells of women with adenomyosis.
    Author: Yang JH, Chen MJ, Wu MY, Chen YC, Yang YS, Ho HN.
    Journal: Fertil Steril; 2006 Nov; 86(5):1459-65. PubMed ID: 16989825.
    Abstract:
    OBJECTIVE: To examine changes in local cytokine production in the eutopic endometrium of adenomyosis after treatment with medroxyprogesterone acetate (MPA) and danazol. DESIGN: Prospective cohort study. SETTING: Tertiary university hospital. PATIENT(S): Twenty-four women with adenomyosis (study group) and 22 women without adenomyosis (control group). INTERVENTION(S): Eutopic endometrium was separated into single endometrial stromal cells (ESCs), and was cultured in vitro alone, with MPA (10(-7) M), or with danazol (10(-7) M) for 8 days. MAIN OUTCOME MEASURE(S): Messenger RNA expression of interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha in ESCs, and their concentrations in the supernatants of ESCs. RESULT(S): A significant decrease of IL-6 concentration in the supernatant, measured by ELISA, was found with time of ESCs cultured with MPA and danazol in the control group, but not in adenomyosis. The IL-6 mRNA in ESCs determined by real-time quantitative polymerase chain, as well as its concentration in the supernatant, was much higher in adenomyosis than that in the control group after treatment with MPA and danazol for 8 days. CONCLUSION(S): Medroxyprogesterone acetate and danazol appeared to have a decreased effect on the suppression of IL-6 liberated by ESCs in adenomyosis. This aberrant secretion of IL-6 might play a role in the formation of ectopic endometrial implants in adenomyosis.
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