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  • Title: Intestinal absorption of macromolecules and epithelial cell surface glycosylation in suckling rats nursed on mothers fed low-protein diet-I.
    Author: Babbar HS, Jaswal VM, Gupta R, Mahmood A.
    Journal: Biol Neonate; 1990; 58(2):104-11. PubMed ID: 1699611.
    Abstract:
    The effect of feeding 8% protein (low-protein; LP) diet to lactating rats has been studied on the absorption of macromolecules and the glycosylation of enterocytes in suckling animals. The absorption of 125I-labelled bovine serum albumin, gamma-globulin and alpha-lactalbumin was 24-314% more in pups nursed on mothers fed LP diet compared to the pair-fed controls. The observed enhancement in protein absorption was associated with a significant increase in the binding of these proteins to microvillus membranes (MVM). The sialic acid content of brush borders was unaltered but the fucose level was augmented (p less than 0.01) in pups nursed on rats fed LP diet. The binding of 125I-labelled wheat germ agglutinin and Ulex europeus agglutinin I to MVM was in agreement to the data on sialic acid and fucose levels of the membranes. The binding of peanut agglutinin to MVM was 30% low in pups from LP-diet-fed animals. The incorporation of (14C) D-mannose into MVM was essentially unaffected but that of (14C) N-acetylglucosamine was reduced in pups reared on mothers given LP diet. These findings suggest that the quality of maternal nutrition affects the absorption of macromolecules and the glycosylation in developing rat intestine.
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