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  • Title: A randomized prospective trial comparing different regimens of oral sodium phosphate and polyethylene glycol-based lavage solution in the preparation of patients for colonoscopy.
    Author: Rostom A, Jolicoeur E, Dubé C, Grégoire S, Patel D, Saloojee N, Lowe C.
    Journal: Gastrointest Endosc; 2006 Oct; 64(4):544-52. PubMed ID: 16996347.
    Abstract:
    BACKGROUND: Regulatory agencies have warned clinicians regarding the risk of electrolyte abnormalities if more than two 45-mL bottles of oral sodium phosphate (NaP) solution are administered within a 24-hour period. OBJECTIVE: To compare the efficacy, safety, and tolerability of different regimens of oral NaP and polyethylene glycol (PEG). DESIGN: Randomized controlled trial. SETTING: Teaching hospital outpatient endoscopy clinic. PATIENTS: Two hundred outpatients without comorbidities who underwent routine colonoscopy. INTERVENTIONS: Two bottles of NaP, 6, 12, or 24 hours apart; or 4 L PEG. MAIN OUTCOME MEASUREMENTS: Bowel preparation quality, patient tolerability, and electrolyte changes. RESULTS: The 12- and 24-hour NaP achieved better cleansing than the 6-hour NaP or PEG. Only 8.5% and 8.3% of patients in the 24- and 12-hour NaP had poor preparations, respectively, compared with 15.6% and 23.4% in the 6-hour NaP and PEG, respectively. The poorer preparation scores with PEG were partly because of a greater amount of colonic fluid. There were no relevant electrolyte changes with PEG, whereas hypokalemia, hypocalcemia, or hyperphosphatemia developed in 5% to 57% of patients on NaP. All regimens were poorly tolerated by patients. LIMITATIONS: The study was likely underpowered to detect small group differences in electrolytes. CONCLUSIONS: A 24- or 12-hour NaP bowel preparation strategy was more effective than NaP 6 hours apart or PEG. PEG use is associated with more residual colonic fluid but represents an alternative to NaP in some clinical situations.
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