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  • Title: Isobrassinin and its analogues: novel types of antiproliferative agents.
    Author: Csomós P, Zupkó I, Réthy B, Fodor L, Falkay G, Bernáth G.
    Journal: Bioorg Med Chem Lett; 2006 Dec 15; 16(24):6273-6. PubMed ID: 16997552.
    Abstract:
    Isobrassinin (2-(S-methyldithiocarbamoylaminomethyl)indole (7a), a regioisomer of the cruciferous phytoalexin brassinin (1), exerted marked antiproliferative effects on the HeLa, A431 and MCF7 cell lines (>78.6% inhibition at 30muM). For structure-activity relationships, further analogues were synthesized. The highest cytotoxic effect was displayed by 2-phenylimino-1,3-thiazino[5,6-b]indole (10) (10 microM, 76.8%-HeLa and 46.3%-MCF7). The effect of the natural phytoalexin brassinin was also determined.
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