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  • Title: Clinical management of BRCA1 and BRCA2 mutation carriers.
    Author: Domchek SM, Weber BL.
    Journal: Oncogene; 2006 Sep 25; 25(43):5825-31. PubMed ID: 16998496.
    Abstract:
    The cancer susceptibility genes BRCA1 and BRCA2 appear to be responsible for virtually all hereditary breast ovarian families, and a smaller subset of hereditary site-specific breast cancer families. Fortunately, effective strategies have been developed to reduce the risk for the development of breast and ovarian cancer in women with BRCA1/2 mutations, making genetic testing for these mutations an important part of the management at women with a strong family history of these diseases. Here, we review the current evidence for risk reduction strategies and outline future research directions.
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