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  • Title: Anticaries potential of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice.
    Author: Pfarrer AM, McQueen CM, Lawless MA, Rapozo-Hilo M, Featherstone JD.
    Journal: Compend Contin Educ Dent; 2005 Sep; 26(9 Suppl 1):41-6. PubMed ID: 16999009.
    Abstract:
    The objective of this research was to evaluate the anticaries potential of stabilized stannous fluoride and sodium hexametaphosphate dentifrice using a series of laboratory studies. In a study of fluoride uptake into demineralized enamel, the stannous fluoride/sodium hexametaphosphate dentifrice exhibited fluoride uptake comparable to the clinically proven stannous fluoride and silica dentifrice. Under lesion progression pH-cycling conditions, the stabilized stannous fluoride/sodium hexametaphosphate dentifrice was shown to protect teeth against lesion initiation and progression almost completely, and was comparable to conventional, clinically proven dentifrices. This series of well-controlled and validated in vitro studies demonstrates the anticaries potential of the stabilized stannous fluoride/sodium hexametaphosphate dentifrice. These in vitro results suggest that the stabilized stannous fluoride/sodium hexametaphosphate dentifrice may provide enhanced anticaries performance relative to a sodium fluoride control dentifrice. These results are reflective of the clinical benefits previously reported for stabilized stannous fluoride/sodium hexametaphosphate dentifrices.
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