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  • Title: Prognostic value of myocardial perfusion contrast echocardiography in patients with suggested or known ischemic heart disease.
    Author: Basic D, Siu SC, Skyba DM, Sloggett C, Jamorski M, Iwanochko RM, Yu EH.
    Journal: J Am Soc Echocardiogr; 2006 Oct; 19(10):1203-10. PubMed ID: 17000358.
    Abstract:
    OBJECTIVE: We sought to determine the prognostic value of myocardial contrast echocardiography (MCE) in patients with known or suggested coronary artery disease compared with technetium-99m sestamibi single photon emission computed tomography (SPECT)-myocardial perfusion imaging (MPI). BACKGROUND: The prognostic value of SPECT-MPI is well established for patients with coronary artery disease. It is less well defined by MCE. METHODS: In all, 51 consecutive patients with suggested coronary artery disease prospectively underwent MCE and SPECT-MPI at baseline and after dipyridamole infusion. MCE and SPECT-MPI were independently analyzed for myocardial perfusion. Cardiac events during the follow-up period were determined, and event-free survival was calculated for MCE and SPECT-MPI techniques separately. RESULTS: MCE (log rank P < .005) and SPECT-MPI (log rank P < .05) demonstrated equivalent event-free survival. The negative predictive value for events for both MCE and SPECT-MPI was 100%. CONCLUSION: MCE accurately classifies patients at risk for cardiac events and provides prognostic information comparable with validated SPECT-MPI techniques.
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