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  • Title: [Effect of adaptation to periodic hypoxia on bioelectric activity of cardiomyocytes and cardiac resistance to contractive and arrhythmogenic effects of excessive calcium].
    Author: Meerson FZ, Vovk VI.
    Journal: Kardiologiia; 1990 Jul; 30(7):83-7. PubMed ID: 1700182.
    Abstract:
    The experiments with isolated hearts from the rats adaptive to a periodic exposure to hypoxia in the barochamber revealed a significant decrease in the contractile and arrhythmogenic effects of high Ca2+ concentrations. With low sodium solution, the contracture and the resting potential depression of cardiomyocytes in the cardiac papillary muscles turned to be less pronounced during adaptation. Increasing the concentration of Ca2+ in the washing solution resulted in lower resting potential, amplitude and duration of the action potential; hypoxic adaptation prevented the changes to a great extent. Whether the changes found may contribute to the anti-arrhythmic effect of periodic hypoxic adaptation is discussed in the paper.
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