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  • Title: c-Fos immunoreactivity in selected brain regions of rats after heat exposure and pyrogen administration.
    Author: du Plessis I, Mitchell D, Niesler C, Laburn HP.
    Journal: Brain Res; 2006 Nov 20; 1120(1):124-30. PubMed ID: 17005162.
    Abstract:
    We determined c-Fos immunoreactivity (Fos-IR) in selected hypothalamic nuclei, the organum vasculosum of the laminae terminals (OVLT) and somatosensory cortex of rats after hyperthermia induced by exogenous heat exposure, Gram-negative or Gram-positive pyrogen administration. The magnitude of Fos-IR was similar in thermoregulatory hypothalamic nuclei of rats after heat exposure or lipopolysaccharide (LPS) injection, despite the different origins of the hyperthermias. Heat-induced hyperthermia was associated with increased Fos-IR in the somatosensory cortex. LPS, but not heat exposure or injection of killed Staphylococcus aureus cells activated OVLT neurons. The OVLT may thus not be a port of entry for humoral mediators of Gram-positive bacterial fevers.
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