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  • Title: Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.
    Author: Warshawsky AM, Alt CA, Brozinick JT, Harkness AR, Hawkins ED, Henry JR, Matthews DP, Miller AR, Misener EA, Montrose-Rafizadeh C, Rhodes GA, Shen Q, Vance JA, Udodong UE, Wang M, Zhang TY, Zink RW.
    Journal: Bioorg Med Chem Lett; 2006 Dec 15; 16(24):6328-33. PubMed ID: 17005394.
    Abstract:
    PPAR ligands with varied subtype selectivity have been synthesized using an achiral aminomethyl dihydrocinnamate template. Several compounds in this series have demonstrated potent plasma glucose and triglyceride lowering capability in rodent models of type 2 diabetes.
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